Description

(1As,8R,8Ar,8Bs)-8-[[(Aminocarbonyl)Oxy]Methyl]-1,1A,2,8,8A,8B-Hexahydro-6,8A-Dimethoxy-1,5-Dimethylazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione is a complex heterocyclic compound featuring an azirino-pyrrolo-indole tricyclic core, which is of significant interest in advanced organic synthesis and pharmaceutical research. This molecule's intricate structure makes it a valuable key intermediate or reference standard for developing novel bioactive compounds, particularly in oncology and antimicrobial research. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in cutting-edge medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex natural product analogs and potential drug candidates.
• Medicinal Chemistry Research: Used as a reference compound or a starting material for structure-activity relationship (SAR) studies targeting specific biological pathways.
• Oncology Research: Investigated for its potential as a core scaffold in the development of novel antitumor agents due to its fused indole-dione structure.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition or receptor binding mechanisms.
• Academic Synthesis Studies: Utilized in advanced organic chemistry laboratories to demonstrate complex multi-step synthetic methodologies.
• Process Development: Acts as a standard for developing and scaling up synthetic routes for related high-value chemical entities.

Basic Information

Item	Details
Product Name	(1As,8R,8Ar,8Bs)-8-[[(Aminocarbonyl)Oxy]Methyl]-1,1A,2,8,8A,8B-Hexahydro-6,8A-Dimethoxy-1,5-Dimethylazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione
CAS No.	74985-82-3
Molecular Formula	C19H23N3O7
Molecular Weight	405.40 g/mol
Synonyms	8-[(Aminocarbonyl)oxy]methyl-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione derivative; Mitomycin derivative analog; 74985-82-3; (1aS,8R,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
EINECS	Contact for details

Quality Control

Our (1As,8R,8Ar,8Bs)-8-[[(Aminocarbonyl)Oxy]Methyl]-1,1A,2,8,8A,8B-Hexahydro-6,8A-Dimethoxy-1,5-Dimethylazirino[2',3':3,4]Pyrrolo[1,2-A]Indole-4,7-Dione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere at lower temperatures (e.g., -20°C) to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.