Description

2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylic Acid is a specialized dihydropyridine derivative, a key structural motif in medicinal chemistry. This compound matters as a versatile pharmaceutical intermediate and a crucial building block for research into calcium channel modulators. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel 1,4-dihydropyridine-based calcium channel blockers and other therapeutic agents.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to develop new drug candidates targeting cardiovascular and neurological pathways.
• Chemical Synthesis Building Block: Employed in organic synthesis for constructing complex heterocyclic compounds due to its reactive carboxylic acid and dihydropyridine functional groups.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling of related APIs.
• Academic & Institutional Research: Applied in biochemical and pharmacological studies to investigate ion channel function and modulation.

Basic Information

Product Name	2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylic Acid
CAS No.	74936-81-5
Molecular Formula	C16H16N2O6
Molecular Weight	332.31 g/mol
Synonyms	3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid; Hantzsch Ester derivative; DHP derivative; Nitrophenyl DHP dicarboxylate; 3-Nitrophenyl DHP; 1,4-DHP-3,5-dicarboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting comprehensive test results, including assay and impurity profiles, are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider conditions under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.