Description

Pyronaridine CAS NO 74847-35-1 is a potent synthetic antimalarial agent belonging to the mannich base class of compounds. It is a critical active pharmaceutical ingredient (API) valued for its efficacy against chloroquine-resistant strains of *Plasmodium falciparum*. This compound is essential for manufacturers in the pharmaceutical industry developing combination therapies for the treatment of acute, uncomplicated malaria. Its role is pivotal in global health initiatives aimed at combating malaria in endemic regions.

Application

• Pharmaceutical API: Primary use as the active ingredient in antimalarial combination therapies, most notably in fixed-dose combinations with artesunate (Pyramax®).
• Malaria Treatment: Formulation into tablets and other dosage forms for the treatment of acute, uncomplicated malaria caused by *P. falciparum* and *P. vivax*.
• Drug Development: Serves as a key compound in preclinical and clinical research for new antimalarial drug formulations and delivery systems.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for drug testing and verification.
• Global Health Procurement: Supplied for large-scale manufacturing of medicines distributed through international health organizations and aid programs.

Basic Information

Product Name	Pyronaridine
CAS No.	74847-35-1
Molecular Formula	C₂₉H₃₂ClN₅O₂
Molecular Weight	518.05 g/mol
Synonyms	Pyronaridine Tetraphosphate; PND; Benzo[b][1,5]naphthyridin-10-ol, 2-methoxy-7-chloro-10-[3,5-bis(pyrrolidin-1-ylmethyl)-4-hydroxyanilino]-; Malaridine; 7351; RP-5337; CI-679
EINECS	Contact for details

Quality Control

Our Pyronaridine is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) are provided with each batch, detailing specifications for identity, purity, and related substances. We support compliance with cGMP and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.