Description

(2R,3R)-2,3-Bis(2,2-Dimethyl-1-Oxopropoxy)-Butanedioic Acid 1-Methyl Ester is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters because it provides a protected diacid derivative, offering precise stereochemical control for constructing complex molecular architectures. It is primarily needed by research and development laboratories and production facilities in the pharmaceutical and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly those requiring specific (2R,3R) stereochemistry.
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure compounds for catalysis and material science research.
• Peptidomimetics & Prodrug Development: Serves as a protected dicarboxylic acid derivative for constructing peptide analogs and designing prodrugs with enhanced bioavailability.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where high stereochemical purity is required.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.

Basic Information

Product Name	(2R,3R)-2,3-Bis(2,2-Dimethyl-1-Oxopropoxy)-Butanedioic Acid 1-Methyl Ester
CAS No.	74817-72-4
Molecular Formula	C17H28O9
Molecular Weight	376.40 g/mol
Synonyms	(2R,3R)-2,3-Bis(pivaloyloxy)succinic Acid 1-Methyl Ester; (2R,3R)-2,3-Di(pivaloyloxy)succinic Acid Monomethyl Ester; (2R,3R)-2,3-Di-O-pivaloyl-D-tartaric Acid Monomethyl Ester; (2R,3R)-2,3-Di-O-pivaloyl-L-tartaric Acid Monomethyl Ester (enantiomer); Methyl (2R,3R)-2,3-Bis(2,2-dimethylpropanoyloxy)succinate; (2R,3R)-2,3-Bis(2,2-dimethylpropionyloxy)butanedioic Acid Methyl Ester; DIPT Monomethyl Ester (common abbreviation); Contact for EINECS details.

Quality Control

Our (2R,3R)-2,3-Bis(2,2-Dimethyl-1-Oxopropoxy)-Butanedioic Acid 1-Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and stereochemical purity, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed HPLC/Chiral HPLC data are provided to confirm identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.