Description

D-Glutamine Methyl Ester Hydrochloride is a protected derivative of the non-essential amino acid glutamine, specifically designed for advanced peptide synthesis and biochemical research. This high-purity building block is critical for researchers and manufacturers requiring precise stereochemical control and minimal racemization during coupling reactions. It is primarily utilized by pharmaceutical R&D teams, peptide synthesis specialists, and academic institutions focused on developing novel therapeutic agents and conducting metabolic studies.

Application

• Peptide Synthesis: Serves as a key protected intermediate for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Research: Used in the discovery and development of new drug candidates, particularly in oncology, metabolic disorders, and neurology.
• Biochemical Probes: Acts as a precursor for labeled compounds (e.g., isotopic, fluorescent) used in metabolic pathway tracing and imaging studies.
• Enzyme Substrate Studies: Employed in research on glutaminase and transglutaminase enzymes to understand their mechanism and inhibition.
• Nutraceutical Development: Investigated for potential applications in specialized amino acid formulations and metabolic supplements.
• Chemical Biology: Utilized to incorporate the D-glutamine moiety into engineered proteins and bioactive molecules to alter stability and function.

Basic Information

Product Name	D-Glutamine Methyl Ester Hydrochloride
CAS No.	74817-54-2
Molecular Formula	C6H13ClN2O3
Molecular Weight	196.63 g/mol
Synonyms	D-Gln-OMe·HCl; Methyl D-glutaminate hydrochloride; (R)-2-Amino-4-carbamoylbutanoic acid methyl ester hydrochloride; D-Glutamine acid methyl ester hydrochloride; Methyl (R)-2-amino-4-carbamoylbutanoate hydrochloride; (R)-Methyl 2-amino-4-carbamoylbutanoate hydrochloride; D-Glutamine methyl ester HCl
EINECS	Contact for details

Quality Control

Our D-Glutamine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for research and synthesis applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.