Description

Croscarmellose Sodium is a super-disintegrant derived from cross-linked sodium carboxymethylcellulose. Its primary value lies in its exceptional ability to rapidly absorb water and swell, promoting the quick disintegration and dissolution of solid dosage forms. This makes it a critical functional excipient for manufacturers in the pharmaceutical industry seeking to enhance drug bioavailability and performance.

Application

• As a super-disintegrant in immediate-release tablets and capsules to ensure rapid breakdown in the gastrointestinal tract.
• Used in orally disintegrating tablets (ODTs) and fast-melt formulations to provide a pleasant patient experience.
• Improves the dissolution rate and bioavailability of poorly soluble active pharmaceutical ingredients (APIs).
• Employed in the formulation of granules and powders for sachets or reconstitution.
• Functions as a suspending and stabilizing agent in certain liquid and semi-solid pharmaceutical preparations.
• Can be utilized in select food product applications as a stabilizer or texture modifier, where regulations permit.

Basic Information

Product Name	Croscarmellose Sodium
CAS No.	74811-65-7
Molecular Formula	(C6H7O2(OH)2(CH2COONa))n
Molecular Weight	~90,000 to ~700,000 (Polymer)
Synonyms	Crosscarmellose Sodium; Sodium Croscarmellose; Cross-Linked Sodium Carboxymethylcellulose; Modified Cellulose Gum; CCS; Ac-Di-Sol® (Trade Name); Nymcel ZSX® (Trade Name); Vivasol® (Trade Name); Cross-Linked CMC-Na
EINECS	Contact for details

Quality Control

Our Croscarmellose Sodium is manufactured and tested to meet the stringent requirements of major pharmacopoeias, including USP-NF, Ph. Eur., and JP. Each batch is supported by a comprehensive Certificate of Analysis (COA) verifying identity, purity, and functional performance. We operate under a cGMP-compliant quality management system to ensure supply reliability and regulatory support for global pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect performance.

Specification

Item	Specification
Identification (IR)	Conforms
Appearance	White or off-white, fibrous powder
pH (1% suspension)	5.0 - 7.0
Loss on Drying	≤ 10.0 %
Sodium Chloride & Sodium Glycolate	≤ 0.5 %
Water Absorption	≥ 23.0 mL/g
Settling Volume	10.0 - 30.0 mL
Heavy Metals	≤ 10 ppm
Microbial Enumeration Tests	Meets Ph. Eur. / USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.