Description

Amberlite IRP-69 is a pharmaceutical-grade cation exchange resin, widely recognized for its role as a tablet disintegrant and taste-masking agent. Its primary value lies in its ability to rapidly absorb water and swell, facilitating the quick breakdown of solid dosage forms in the gastrointestinal tract. This makes it an essential excipient for formulators in the pharmaceutical industry seeking to enhance drug dissolution rates and improve patient compliance for both immediate-release and orally disintegrating tablet (ODT) applications.

Application

• Primary excipient as a superdisintegrant in immediate-release tablets and capsules.
• Key component in the formulation of orally disintegrating tablets (ODTs) and fast-melt dosage forms.
• Used for taste masking of bitter active pharmaceutical ingredients (APIs) through complexation.
• Employed in controlled-release drug delivery systems to modify API release profiles.
• Applicable in pharmaceutical suspensions as a stabilizing and suspending agent.
• Potential use in nutraceutical and dietary supplement formulations requiring rapid disintegration.

Basic Information

Product Name	Amberlite IRP-69
CAS No.	55464-99-8
Molecular Formula	(C8H7SO3Na)n
Molecular Weight	206.19 (monomer)
Synonyms	Sodium Polystyrene Sulfonate; Polystyrene Sulfonic Acid Sodium Salt; PSSNa; Cation Exchange Resin, Sodium Form; USP Type I Cation Exchange Resin; Kionex; Kayexalate (related product); Sodium Polystyrene Sulphonate; Sodium Poly(styrenesulfonate)
EINECS	Contact for details

Quality Control

Our Amberlite IRP-69 is manufactured and tested to meet stringent pharmaceutical excipient standards. Quality assurance protocols are designed to ensure batch-to-batch consistency, purity, and performance as a superdisintegrant. Certificates of Analysis (COA) documenting key parameters such as exchange capacity, particle size distribution, and heavy metal content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect flow properties and performance.

Specification

Item	Specification
Appearance	Off-white to light tan powder
Identification (IR)	Conforms
Assay (Sodium Content)	9.4 - 11.0 %
Exchange Capacity	≥ 2.8 mEq/g (dry basis)
Particle Size Distribution	Specification available upon request
Loss on Drying	≤ 5.0 %
Heavy Metals	≤ 20 ppm
Microbial Limits	Meets USP/EP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.