Description

3-((4-Azidophenyl)Dithio)Propionic n-Hydroxysuccinimide is a heterobifunctional crosslinking reagent featuring a cleavable disulfide bond and a photoactivatable aryl azide group. This compound matters for researchers and manufacturers requiring precise, reversible conjugation strategies in complex biomolecular systems. It is primarily needed by professionals in bioconjugation, proteomics, and advanced materials science for applications such as surface functionalization and the study of protein-protein interactions.

Application

• Bioconjugation reagent for crosslinking proteins, peptides, and other biomolecules.
• Surface modification and functionalization of nanoparticles and biosensors.
• Proteomics research, including affinity labeling and pull-down assays.
• Development of cleavable antibody-drug conjugates (ADCs) and other therapeutic bioconjugates.
• Photoaffinity labeling to study ligand-receptor or protein-protein interactions.
• Immobilization of biomolecules onto solid supports via the photoreactive azide group.
• Fabrication of smart hydrogels and biomaterials with stimuli-responsive (redox-cleavable) properties.
• Chemical biology tool for introducing reversible disulfide linkages into synthetic polymers.

Basic Information

Product Name	3-((4-Azidophenyl)Dithio)Propionic n-Hydroxysuccinimide
CAS No.	74676-98-5
Molecular Formula	C17H15N4O4S2
Molecular Weight	403.45 g/mol
Synonyms	3-((4-Azidophenyl)disulfanyl)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; 4-Azidophenyl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxopropyl disulfide; NHS-SS-Phenyl Azide; SSA; Heterobifunctional Crosslinker (NHS ester-Aryl Azide, cleavable); 3-(2,5-Dioxopyrrolidin-1-yl)-3-oxopropyl (4-azidophenyl) disulfide; N-Succinimidyl 3-((4-azidophenyl)dithio)propionate
EINECS	Contact for details

Quality Control

Our 3-((4-Azidophenyl)Dithio)Propionic n-Hydroxysuccinimide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance. We adhere to relevant quality standards, and custom purity grades or analytical packages are available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, acetonitrile
Water Content (KF)	≤ 1.0%
Functional Test	Conforms (NHS ester & aryl azide activity)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.