Description

Laurdan (CAS NO 74515-25-6) is a highly sensitive and versatile fluorescent membrane probe. It matters because its emission spectrum exhibits a significant solvatochromic shift, making it an indispensable tool for studying membrane fluidity, lipid order, and phase transitions in model and biological membranes. Researchers in biophysics, pharmaceutical development, and cell biology need it to investigate lipid raft dynamics, protein-lipid interactions, and the effects of various compounds on membrane properties.

Application

• Membrane Fluidity and Phase Studies: Primary application for detecting lipid order and phase separation (gel vs. liquid-disordered) in lipid bilayers.
• Lipid Raft Characterization: Used in fluorescence spectroscopy and microscopy to visualize and quantify the dynamics of membrane microdomains.
• Drug-Membrane Interaction Screening: Assess how pharmaceutical compounds, peptides, or toxins alter membrane physical properties.
• Model Membrane Research: Essential for experiments with liposomes, giant unilamellar vesicles (GUVs), and supported lipid bilayers.
• Cellular Membrane Imaging: Applied in live-cell imaging to monitor changes in plasma membrane organization in real-time.
• Biophysical Assay Development: Serves as a key component in high-throughput or diagnostic assays measuring membrane integrity or cholesterol content.

Basic Information

Product Name	Laurdan
CAS No.	74515-25-6
Molecular Formula	C26H39NO2
Molecular Weight	397.60 g/mol
Synonyms	6-Dodecanoyl-2-dimethylaminonaphthalene; 6-Lauroyl-2-dimethylaminonaphthalene; 2-Dimethylamino-6-lauroylnaphthalene; 2-Dimethylamino-6-dodecanoylnaphthalene; LAURDAN; Environment-Sensitive Probe LAURDAN; GP (Generalized Polarization) Probe
EINECS	Contact for details

Quality Control

Our Laurdan is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, critical for reproducible experimental results. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic analysis for functional performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Light yellow to yellow powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Fluorescence Properties	Ex/Em in suitable solvent conforms to reference
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.