Description

2-Chloro-4-[3-(Trifluoromethyl)Phenyl]-5-Thiazolecarboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block characterized by its thiazole core and trifluoromethylphenyl substituent. This compound matters for its role as a critical synthetic intermediate in the development of advanced active ingredients, offering a unique combination of structural motifs that influence biological activity and physicochemical properties. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for targets requiring the thiazole pharmacophore.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioavailability and stability.
• Material Science Research: Serves as a precursor for specialized ligands, organic semiconductors, or liquid crystals due to its conjugated system and halogenated aromatic ring.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function or cellular processes.
• Custom Synthesis & Contract Manufacturing: A starting material for custom chemical synthesis services catering to specialized R&D projects.

Basic Information

Product Name	2-Chloro-4-[3-(Trifluoromethyl)Phenyl]-5-Thiazolecarboxylic Acid Ethyl Ester
CAS No.	74476-49-6
Molecular Formula	C13H9ClF3NO2S
Molecular Weight	335.73 g/mol
Synonyms	Ethyl 2-Chloro-4-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate; 2-Chloro-4-(3-trifluoromethylphenyl)thiazole-5-carboxylic Acid Ethyl Ester; 5-Thiazolecarboxylic Acid, 2-chloro-4-[3-(trifluoromethyl)phenyl]-, ethyl ester; 74476-49-6; Ethyl 2-chloro-4-(α,α,α-trifluoro-m-tolyl)thiazole-5-carboxylate
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-[3-(Trifluoromethyl)Phenyl]-5-Thiazolecarboxylic Acid Ethyl Ester is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP requirements for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.