Description

2-Mercapto-Isonicotinic Acid Methyl Ester is a versatile sulfur-containing heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its bifunctional structure, featuring both a reactive thiol group and an ester moiety, which enables its use as a key intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection agent development.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging its heterocyclic core for bioactivity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions due to the thiol functionality.
• Material Science Research: Acts as a monomer or modifying agent in the synthesis of functional polymers and advanced materials.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and protein interactions.
• Custom Synthesis Building Block: Provides a versatile scaffold for contract research organizations (CROs) and fine chemical manufacturers engaged in custom synthesis projects.

Basic Information

Product Name	2-Mercapto-Isonicotinic Acid Methyl Ester
CAS No.	74470-33-0
Molecular Formula	C7H7NO2S
Molecular Weight	169.20 g/mol
Synonyms	Methyl 2-mercaptoisonicotinate; 2-Mercaptopyridine-4-carboxylic acid methyl ester; 4-Pyridinecarboxylic acid, 2-mercapto-, methyl ester; Methyl 2-sulfanylisonicotinate; 2-Thiolisonicotinic acid methyl ester; Isonicotinic acid, 2-mercapto-, methyl ester
EINECS	Contact for details

Quality Control

Our 2-Mercapto-Isonicotinic Acid Methyl Ester is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.