Description

2-(Acetylamino)-1-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-2-Deoxy-D-Mannitol is a sophisticated, fully protected carbohydrate derivative, specifically a per-silylated N-acetyl-D-mannosamine derivative. This compound is of critical importance as a key synthetic intermediate and building block in advanced organic and medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of complex glycoconjugates, nucleoside analogs, and other bioactive molecules where precise stereochemistry and protecting group strategy are paramount.

Application

• Glycochemistry Research: Serves as a crucial protected intermediate for the synthesis of complex oligosaccharides, glycopeptides, and glycolipids.
• Nucleoside Analog Synthesis: Used as a chiral precursor in the development of modified nucleosides with potential antiviral or anticancer activity.
• Pharmaceutical Intermediate: Acts as a key building block in the multi-step synthesis of novel drug candidates, particularly in glycoscience-based therapeutics.
• Chemical Biology Probes: Employed in the creation of labeled or tagged sugar analogs for studying carbohydrate-protein interactions and metabolic pathways.
• Process Development: Used in scaling up synthetic routes for carbohydrate-based active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry, especially in stereoselective transformations.

Basic Information

Item	Details
Product Name	2-(Acetylamino)-1-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-2-Deoxy-D-Mannitol
CAS No.	74464-41-8
Molecular Formula	C23H55NO6Si5
Molecular Weight	610.21 g/mol
Synonyms	2-Acetamido-1,3,4,5,6-penta-O-trimethylsilyl-2-deoxy-D-mannitol; 2-Deoxy-2-acetamido-1,3,4,5,6-penta-O-trimethylsilyl-D-mannitol; N-Acetyl-1,3,4,5,6-penta-O-trimethylsilyl-D-mannosamine; Penta-O-trimethylsilyl-N-acetyl-D-mannosamine; Protected N-Acetyl-D-mannosamine Derivative; TMS-protected D-Mannosamine; Per-TMS N-Acetylmannosamine
EINECS	Contact for details

Quality Control

Our 2-(Acetylamino)-1-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-2-Deoxy-D-Mannitol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.