Description

2,2-Difluoroethyl Trifluoromethanesulfonate is a high-value fluorinated building block and alkylating agent essential for advanced organic synthesis. Its primary commercial value lies in its ability to efficiently introduce the 2,2-difluoroethyl group into complex molecular architectures, a key step in developing compounds with enhanced metabolic stability and lipophilicity. This reagent is critically needed by R&D and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs where the difluoroethyl moiety improves bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where fluorination enhances activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a versatile building block for creating novel fluorinated ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of fluorinated monomers and polymers for specialty plastics, coatings, and electronic materials with unique surface properties and chemical resistance.
• PET Tracer Synthesis: Potential use in radiochemistry for labeling compounds with fluorine-18 in Positron Emission Tomography (PET) imaging agent development.
• Cross-Coupling Reactions: Acts as an effective electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.

Basic Information

Item	Details
Product Name	2,2-Difluoroethyl Trifluoromethanesulfonate
CAS No.	74427-22-8
Molecular Formula	C3H3F5O3S
Molecular Weight	214.11 g/mol
Synonyms	2,2-Difluoroethyl Triflate; Trifluoromethanesulfonic Acid 2,2-Difluoroethyl Ester; 2,2-Difluoroethyl Trifluoromethanesulphonate; 2,2-Difluoroethanol Triflate; 2,2-Difluoroethyl Trifluoromethylsulfonate; (2,2-Difluoroethoxy)(trifluoro)-λ6-sulfanone; 2,2-Difluoroethyl Trifluoromethanesulfonate (DFETf)
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoroethyl Trifluoromethanesulfonate is manufactured and tested under strict quality management systems to ensure high purity, consistency, and reliability for sensitive synthetic applications. Our standard grade meets rigorous in-house specifications, with purity typically exceeding 97% (by GC or HPLC). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain product integrity. Keep away from strong bases and nucleophiles.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.55 g/mL
Refractive Index (n20D)	~1.35

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.