Description

N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine is a specialized organosilicon-protected indole derivative, serving as a crucial advanced intermediate in complex organic syntheses. Its primary value lies in its dual silyl protection, which enhances stability and directs reactivity for high-yield, selective transformations in sensitive reaction sequences. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise building blocks for heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex indole-based active pharmaceutical ingredients (APIs) and drug candidates, particularly for neurological and oncological targets.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the indole scaffold imparts specific biological activity.
• Material Science Research: Serves as a precursor for functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, including studies on silyl group migration and protection/deprotection strategies.
• Peptidomimetics & Bioconjugation: Utilized in the design and synthesis of indole-containing peptide analogs and for introducing functional handles into biomolecules.

Basic Information

Product Name	N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine
CAS No.	74421-43-5
Molecular Formula	C18H32N2Si2
Molecular Weight	332.64 g/mol
Synonyms	3-(2-Aminoethyl)-1H-indole, N,N-bis(trimethylsilyl) derivative; 2-(1H-Indol-3-yl)ethanamine, N,N-bis(trimethylsilyl)-; N,N-Bis(trimethylsilyl)tryptamine (protected); BTS-Tryptamine; TMS-protected Tryptamine; N1,N-Bis(trimethylsilyl)tryptamine; 1H-Indole-3-ethanamine, N,N-bis(trimethylsilyl)-; Bis(trimethylsilyl)tryptamine
EINECS	Contact for details

Quality Control

Our N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.