Description

5-Methoxy-N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine is a high-purity, organosilicon-protected indole derivative of significant interest in advanced organic synthesis. This compound serves as a critical, protected synthetic intermediate, enabling the construction of complex molecules with high selectivity and yield. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, particularly those exploring indole-based pharmacophores.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially those targeting neurological and oncological pathways.
• Organic Synthesis Reagent: Used in advanced organic reactions, including palladium-catalyzed cross-couplings and nucleophilic substitutions, where its silyl protecting groups offer strategic advantages.
• Agrochemical Research: Employed in the development of new-generation pesticides and herbicides that utilize functionalized indole structures.
• Material Science Precursor: Investigated as a monomer or precursor for the synthesis of specialized polymers and organic electronic materials.
• Academic & R&D: Essential for methodological studies in synthetic chemistry laboratories focused on heterocyclic and organosilicon chemistry.

Basic Information

Item	Details
Product Name	5-Methoxy-N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine
CAS No.	74421-42-4
Molecular Formula	C19H34N2O2Si2
Molecular Weight	378.66 g/mol
Synonyms	5-Methoxy-N,N-bis(trimethylsilyl)-1H-indole-3-ethanamine; 5-Methoxy-N,N-bis(trimethylsilyl)tryptamine; 3-[2-[Bis(trimethylsilyl)amino]ethyl]-5-methoxy-1H-indole; 5-MeO-N,N-bis-TMS-tryptamine; BIS(TRIMETHYLSILYL)-5-METHOXYTRYPTAMINE; 5-Methoxy-N,N-bis(trimethylsilyl)tryptamine; 74421-42-4; 5-MeO-N,N-bis(trimethylsilyl)tryptamine
EINECS	Contact for details

Quality Control

Our 5-Methoxy-N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.