Description

1-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-2-[(Trimethylsilyl)Amino]-2-Deoxy-D-Mannitol is a highly functionalized, fully protected derivative of D-mannitol, featuring multiple trimethylsilyl (TMS) groups. This compound is a critical advanced intermediate in organic synthesis, valued for its role in constructing complex carbohydrate mimetics and chiral scaffolds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostics, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of nucleoside analogs, glycosidase inhibitors, and other bioactive molecules.
• Carbohydrate Chemistry: Used in the preparation of complex, selectively protected sugar derivatives for glycobiology research and glycoconjugate synthesis.
• Chiral Auxiliary/ Ligand Precursor: The protected amino and polyol structure provides a platform for developing asymmetric catalysts or chiral resolving agents.
• Chemical Derivatization Agent: Employed in analytical chemistry for the silylation of sensitive compounds to enhance volatility for GC-MS analysis.
• Material Science Research: Acts as a monomer or cross-linker precursor for synthesizing novel silicon-containing polymers and dendritic structures.

Basic Information

Product Name	1-O,3-O,4-O,5-O,6-o-Pentakis(Trimethylsilyl)-2-[(Trimethylsilyl)Amino]-2-Deoxy-D-Mannitol
CAS No.	74420-75-0
Molecular Formula	C27H69NO6Si6
Molecular Weight	680.5 g/mol
Synonyms	2-Amino-2-deoxy-1,3,4,5,6-penta-O-trimethylsilyl-D-mannitol; 2-Deoxy-2-[(trimethylsilyl)amino]-D-mannitol pentakis(trimethylsilyl) ether; Hexakis(trimethylsilyl)-2-amino-2-deoxy-D-mannitol; Fully TMS-protected D-mannosamine derivative; Per-TMS D-mannitol amine
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to strict in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.