Description

Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-D-Galactopyranoside CAS NO 74410-43-8 is a key protected carbohydrate intermediate, specifically a silylated galactosamine derivative. This compound is critical for synthetic chemists as it provides a versatile, reactive scaffold for the controlled synthesis of complex oligosaccharides and glycoconjugates. It is primarily utilized in advanced pharmaceutical research and development, particularly for the production of novel glycopeptide antibiotics, carbohydrate-based vaccines, and other bioactive molecules.

Application

• Glycopeptide Synthesis: A crucial building block for the solid-phase and solution-phase synthesis of complex glycopeptides and glycoproteins.
• Oligosaccharide Assembly: Serves as a key intermediate in the convergent synthesis of biologically active oligosaccharides and polysaccharide fragments.
• Pharmaceutical Intermediates: Used in the research and development of carbohydrate-based drugs, including antiviral and anticancer agents.
• Glycoconjugate Vaccine Development: Employed in the creation of synthetic antigen candidates for next-generation conjugate vaccines.
• Chemical Biology Probes: Acts as a precursor for labeled sugars used to study glycosylation pathways and carbohydrate-protein interactions.
• Process Development: Used in scaling up synthetic routes for glycosylated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-D-Galactopyranoside
CAS No.	74410-43-8
Molecular Formula	C18H41NO6Si3
Molecular Weight	463.78 g/mol
Synonyms	Methyl 2-Acetamido-3,4,6-tri-O-trimethylsilyl-2-deoxy-α/β-D-galactopyranoside; 2-Acetamido-3,4,6-tri-O-(trimethylsilyl)-2-deoxy-D-galactopyranoside methyl glycoside; Methyl 2-deoxy-2-acetamido-3,4,6-tri-O-trimethylsilyl-D-galactopyranoside; TMS-protected GalNAc methyl glycoside; Methyl N-acetyl-3,4,6-tri-O-trimethylsilyl-D-galactosaminide; Protected D-Galactosamine derivative; Silylated GalNAc intermediate
EINECS	Contact for details

Quality Control

Our Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-D-Galactopyranoside is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Anomeric mixture)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.