Description

1H-Indole-3-Acetonitrile, 1-(Trimethylsilyl)- is a specialized organosilicon-protected indole derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in the trimethylsilyl (TMS) group, which acts as a protective moiety for the indole nitrogen, enabling selective functionalization and participation in sensitive reactions. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and the production of complex organic materials where precise molecular construction is required.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel indole-based drug candidates, including potential serotonin receptor modulators and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new plant growth regulators and protective agents that leverage the indole scaffold.
• Organic Synthesis Reagent: Serves as a protected precursor in multi-step synthetic routes, including palladium-catalyzed cross-coupling reactions and lithiation-electrophile trapping sequences.
• Material Science Research: Employed in the development of organic semiconductors and advanced polymers where the indole unit contributes to electron-donating properties.
• Academic & R&D Laboratories: A valuable tool for methodological development in synthetic organic chemistry and for exploring new reaction pathways.

Basic Information

Item	Details
Product Name	1H-Indole-3-Acetonitrile, 1-(Trimethylsilyl)-
CAS No.	74367-49-0
Molecular Formula	C₁₃H₁₆N₂Si
Molecular Weight	228.37 g/mol
Synonyms	1-(Trimethylsilyl)-1H-indole-3-acetonitrile; 1H-Indole-3-acetonitrile, 1-(trimethylsilyl)-; 1-TMS-indole-3-acetonitrile; N-Trimethylsilylindole-3-acetonitrile; 3-(Cyanomethyl)-1-(trimethylsilyl)-1H-indole; 1-(Trimethylsilyl)indole-3-acetonitrile; [1-(Trimethylsilyl)-1H-indol-3-yl]acetonitrile
EINECS	Contact for details

Quality Control

Our production of 1H-Indole-3-Acetonitrile, 1-(Trimethylsilyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. Certificates of Analysis (COA) detailing all relevant specifications are provided and available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.