Description

1H-Indole-3-Carboxaldehyde, 1-(Trimethylsilyl)- is a versatile organosilicon-protected indole derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in the trimethylsilyl (TMS) group, which acts as a protective moiety for the indole nitrogen, enhancing stability and directing regioselectivity in subsequent reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex alkaloids, tryptamine derivatives, and novel drug candidates targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the development of advanced pesticides and plant growth regulators that leverage the indole scaffold's bioactivity.
• Material Science Precursor: Serves as a monomer or functional unit in the creation of organic semiconductors, conductive polymers, and advanced organic frameworks (MOFs/COFs).
• Academic & R&D: A valuable reagent for methodological development in organic synthesis, particularly in cross-coupling reactions and heterocyclic chemistry.
• Fine Chemical Production: Employed in the multi-step synthesis of dyes, flavors, fragrances, and other specialty chemicals where indole motifs are required.

Basic Information

Product Name	1H-Indole-3-Carboxaldehyde, 1-(Trimethylsilyl)-
CAS No.	74367-39-8
Molecular Formula	C13H17NOSi
Molecular Weight	231.36 g/mol
Synonyms	1-(Trimethylsilyl)-1H-indole-3-carboxaldehyde; 1H-Indole-3-carboxaldehyde, 1-(trimethylsilyl)-; 1-TMS-indole-3-carboxaldehyde; N-Trimethylsilylindole-3-carboxaldehyde; 3-Formyl-1-(trimethylsilyl)indole; 1-(Trimethylsilyl)indole-3-carbaldehyde; N-TMS-3-indolecarboxaldehyde; 74367-39-8
EINECS	Contact for details

Quality Control

Our 1H-Indole-3-Carboxaldehyde, 1-(Trimethylsilyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.