Description

5-Fluoro-α-Methyl-N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine is a sophisticated organosilicon-protected indole derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its primary value lies in enabling complex, multi-step syntheses where sensitive functional groups require protection, ensuring high yields and purity in the final target molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who are developing novel bioactive compounds and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of central nervous system (CNS) agents and other fluorinated bioactive molecules.
• Agrochemical Research: Used in creating advanced, fluorinated active ingredients for next-generation herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced biological activity and stability.
• Organic Synthesis Reagent: Serves as a protected amine precursor in complex multi-step organic syntheses, where the trimethylsilyl (TMS) groups provide stability under harsh reaction conditions.
• Material Science Precursor: Potential intermediate for synthesizing specialized organic semiconductors, liquid crystals, or photoactive materials that incorporate the indole scaffold.
• Process Chemistry Development: Employed in route scouting and optimization for scalable manufacturing processes of complex organic molecules in pilot plants and kilo-labs.

Basic Information

Product Name	5-Fluoro-α-Methyl-N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine
CAS No.	74367-10-5
Molecular Formula	C19H33FN2Si2
Molecular Weight	364.65 g/mol
Synonyms	1H-Indole-3-ethanamine, 5-fluoro-α-methyl-N,N-bis(trimethylsilyl)-; 5-Fluoro-α-methyl-N,N-bis(trimethylsilyl)-1H-indole-3-ethanamine; N,N-Bis(trimethylsilyl)-5-fluoro-α-methyl-1H-indole-3-ethanamine; 5-Fluoro-α-methyl-N,N-bis(trimethylsilyl)-1H-indole-3-ethanamine; Protected 5-Fluoro Tryptamine Derivative; Fluorinated TMS-Indole Amine; CAS 74367-10-5
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-α-Methyl-N,N(Or N,1)-Bis(Trimethylsilyl)-1H-Indole-3-Ethanamine undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and process development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.