Description

Hydroxypiperaquine is a key pharmaceutical intermediate and active metabolite of piperaquine, an important antimalarial agent. Its primary value lies in its role in the research, development, and quality control of next-generation antimalarial drugs and combination therapies. This compound is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on infectious disease treatment and drug metabolism studies. Hydroxypiperaquine CAS NO 74351-60-3 is critical for ensuring the efficacy and safety profiles of related therapeutic formulations.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced antimalarial drugs and their derivatives.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and formulation of new antimalarial medications, particularly those targeting drug-resistant strains of malaria.
• Metabolite Reference Standard: Essential as an analytical standard in pharmacokinetic and pharmacodynamic studies to quantify piperaquine metabolism in biological samples.
• Quality Control & Assurance: Employed in HPLC and other chromatographic methods to assay the purity and stability of piperaquine-based drug products.
• Biomedical Research: Utilized in in-vitro and in-vivo studies to investigate the mechanism of action, efficacy, and toxicity profiles of antimalarial compounds.
• Combinatorial Therapy Research: A component in the development of fixed-dose combination therapies (e.g., with dihydroartemisinin) to combat malaria.

Basic Information

Product Name	Hydroxypiperaquine
CAS No.	74351-60-3
Molecular Formula	C29H32Cl2N6O
Molecular Weight	527.51 g/mol
Synonyms	1,3-Bis[4-(7-chloro-4-quinolyl)piperazin-1-yl]propan-2-ol; Hydroxypiperaquine Phosphate (salt form); Piperaquine Metabolite; Hydroxy-piperaquine; 74351-60-3; 1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propan-2-ol; WR 268,668 (hydroxy metabolite)
EINECS	Contact for details

Quality Control

Our Hydroxypiperaquine is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specified impurities. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific results for all critical quality attributes. Our quality standards are designed to meet the rigorous demands of pharmaceutical development and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.