Description

(3R)-Spiro[Cholestane-3,1'-Cyclobutan]-2'-One CAS NO 74310-24-0 is a high-purity, steroidal spiro compound characterized by its unique cholestane backbone fused with a cyclobutanone ring. This specific stereochemistry and complex molecular architecture make it a valuable advanced intermediate for pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel therapeutic agents, particularly in exploring steroidal hormone analogs and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel steroidal drugs and hormone receptor modulators.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a critical intermediate in the development and scale-up of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Biochemical Research: Potential use as a probe or precursor in studying sterol metabolism and related biological pathways.

Basic Information

Item	Details
Product Name	(3R)-Spiro[Cholestane-3,1'-Cyclobutan]-2'-One
CAS No.	74310-24-0
Molecular Formula	C30H48O
Molecular Weight	424.71 g/mol
Synonyms	(3R)-Spiro[cholestane-3,1'-cyclobutan]-2'-one; (3R)-Spiro[cholestane-3,1'-cyclobutanone]; (3R)-2'-Oxaspiro[cholestane-3,1'-cyclobutane] (related structural name); Steroidal spiro cyclobutanone; (3R)-Cholestane-spiro-cyclobutan-2-one
EINECS	Contact for details

Quality Control

Our (3R)-Spiro[Cholestane-3,1'-Cyclobutan]-2'-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the (3R) configuration, and spectroscopic identification (NMR, IR, MS). We provide full traceability and documentation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (3R)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.