Description

Cyclobutanecarboxylic Acid, 3-Amino-, Ethyl Ester (6Ci,9Ci) is a specialized chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of complex, biologically active molecules, offering a constrained cyclobutane ring system and functional handles for further derivatization. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of new generation pesticides and herbicides, where the cyclobutane scaffold can impart unique biological activity and stability.
• Asymmetric Synthesis: Serves as a valuable starting material or chiral auxiliary in catalytic asymmetric reactions to construct stereochemically complex molecules.
• Peptidomimetics & Bioisosteres: The constrained amino acid derivative structure is utilized to design and synthesize peptide mimics and bioisosteric replacements in drug design.
• Material Science Research: Investigated as a monomer or functional component for creating novel polymers with specific thermal or mechanical properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Amino-, Ethyl Ester (6Ci,9Ci)
CAS No.	74307-73-6
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	Ethyl 3-Aminocyclobutanecarboxylate; 3-Aminocyclobutanecarboxylic Acid Ethyl Ester; 1-Azabicyclo[2.2.2]octan-3-one, Ethyl Ester (related); (3-Aminocyclobutyl)carboxylic Acid Ethyl Ester; Ethyl 3-Aminocyclobutane-1-carboxylate; 3-Amino-1-cyclobutanecarboxylic Acid Ethyl Ester; Amino Cyclobutane Carboxylate Ethyl Ester
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-Amino-, Ethyl Ester (6Ci,9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.