Description

4-Hydroxy-3-[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-17-One is a key steroidal intermediate featuring a trimethylsilyl-protected phenolic hydroxyl group. This compound is critical for ensuring high-yield, selective reactions in complex synthetic pathways, offering superior stability and handling characteristics compared to its unprotected counterpart. It is primarily utilized by pharmaceutical R&D and manufacturing teams for the synthesis of advanced steroid-based active pharmaceutical ingredients (APIs) and reference standards.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of steroidal hormones and related therapeutic agents.
• API Development: Used in research and process development for novel estrogen receptor modulators and other steroid-derived pharmaceuticals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry: Employed in route scouting and optimization due to its protective group chemistry, enabling more efficient synthetic sequences.
• Biochemical Research: Used in academic and industrial research to study steroid metabolism, receptor binding, and structure-activity relationships (SAR).
• Custom Synthesis: A starting material for the custom synthesis of labeled (e.g., deuterated, C13) steroids for analytical and diagnostic applications.

Basic Information

Product Name	4-Hydroxy-3-[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-17-One
CAS No.	74299-18-6
Molecular Formula	C22H36O3Si
Molecular Weight	376.61 g/mol
Synonyms	3-Trimethylsilyloxyestra-1,3,5(10)-trien-17-one; 3-(Trimethylsilyloxy)estra-1,3,5(10)-trien-17-one; 17-Oxoestra-1,3,5(10)-trien-3-yl trimethylsilyl ether; Estra-1,3,5(10)-trien-17-one, 3-[(trimethylsilyl)oxy]-; 3-TMS-Estrone; Estrone 3-trimethylsilyl ether; Estrone 3-TMS ether
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-17-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Use appropriate handling procedures to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.