Description

3,6α,17β-Tris[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-11β-Ol is a high-purity, steroidal intermediate featuring multiple trimethylsilyl (TMS) protecting groups. This compound is of significant value in advanced organic synthesis, particularly for the production of complex steroid derivatives and active pharmaceutical ingredients (APIs) where selective deprotection strategies are required. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel hormonal therapies and other specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and creating novel steroidal analogs.
• Hormone Analog Synthesis: Serves as a protected precursor in the manufacture of estrane-derived hormone analogs and metabolites.
• Fine Chemical Production: Employed in the production of high-value, specialized fine chemicals for diagnostic and biochemical applications.
• Process Chemistry: Utilized in process development and scale-up activities within regulated pharmaceutical manufacturing.

Basic Information

Product Name	3,6α,17β-Tris[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-11β-Ol
CAS No.	74298-85-4
Molecular Formula	C30H52O4Si3
Molecular Weight	561.0 g/mol
Synonyms	11β-Hydroxy-3,6α,17β-tris(trimethylsilyloxy)estra-1,3,5(10)-triene; Estra-1,3,5(10)-trien-11β-ol, 3,6α,17β-tris[(trimethylsilyl)oxy]-; 3,6α,17β-Tris-O-(trimethylsilyl)estradiol 11β-ol derivative; TMS-protected 11β-hydroxyestradiol triether; 11β-Hydroxyestradiol 3,6α,17β-tris(TMS) ether
EINECS	Contact for details

Quality Control

Our 3,6α,17β-Tris[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Trien-11β-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.