Description

6α-Methoxy-3,17β-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Triene is a key protected steroid intermediate, specifically a trimethylsilyl (TMS) ether derivative of a methoxy-estratriene. This compound matters for its role as a versatile synthon in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of hormonal compounds, where its protected hydroxyl groups allow for selective functionalization and improved reaction stability.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of steroidal drugs, including potential hormone therapies and anti-inflammatory agents.
• Research & Development: Used in academic and industrial R&D for exploring novel steroid derivatives and metabolic pathways.
• Fine Chemical Synthesis: Employed in the production of high-value, complex organic molecules for specialized applications.
• Reference Standard: Serves as a chromatographic or spectroscopic reference standard for quality control in steroid manufacturing.
• Process Chemistry: Utilized in scale-up and process optimization for the commercial production of steroid APIs.

Basic Information

Item	Details
Product Name	6α-Methoxy-3,17β-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Triene
CAS No.	74298-82-1
Molecular Formula	C25H42O3Si2
Molecular Weight	446.78 g/mol
Synonyms	6α-Methoxyestra-1,3,5(10)-triene-3,17β-diyl bis(trimethylsilyl) ether; 6α-Methoxy-3,17β-bis(trimethylsiloxy)estra-1,3,5(10)-triene; 3,17β-Bis-O-(trimethylsilyl)-6α-methoxyestra-1,3,5(10)-triene; 6-Methoxy-3,17-bis(trimethylsiloxy)estra-1,3,5(10)-triene; TMS-protected 6α-methoxy estradiol derivative; 6α-Methoxyestradiol 3,17-bis(trimethylsilyl) ether; 74298-82-1
EINECS	Contact for details

Quality Control

Our 6α-Methoxy-3,17β-Bis[(Trimethylsilyl)Oxy]Estra-1,3,5(10)-Triene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.