Description

8-(Bromomethyl)-1,4-Dioxaspiro[4.5]Decane is a versatile brominated spirocyclic acetal, a key protected intermediate in advanced organic synthesis. Its value lies in the reactive bromomethyl group, which allows for efficient functionalization and chain extension, and the acid-labile 1,3-dioxolane ring, which serves as a protected carbonyl equivalent. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of spirocyclic drug candidates, including potential treatments for neurological disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the spiro structure can contribute to unique biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Employed to introduce functional spirocyclic units into polymers, modifying thermal properties, rigidity, and solubility.
• Cross-Coupling Reactions: The bromomethyl moiety acts as an effective electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck).
• Protected Aldehyde Synthon: The 1,4-dioxaspiro[4.5]decane system is a standard protecting group for cyclohexanone, allowing selective reactions elsewhere on the molecule.

Basic Information

Item	Details
Product Name	8-(Bromomethyl)-1,4-Dioxaspiro[4.5]Decane
CAS No.	74286-87-6
Molecular Formula	C10H17BrO2
Molecular Weight	249.15 g/mol
Synonyms	8-(Bromomethyl)-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decane-8-methanol, 8-bromomethyl-; (8-Bromomethyl)-1,4-dioxaspiro[4.5]decane; Bromomethyl Spiroacetal; 2-(3-Bromopropyl)-1,4-dioxaspiro[4.5]decane (tautomeric form); Protected 4-(Bromomethyl)cyclohexanone; Cyclohexanone, 4-(bromomethyl)-, ethylene ketal
EINECS	Contact for details

Quality Control

Our 8-(Bromomethyl)-1,4-Dioxaspiro[4.5]Decane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.