Description

1-Ethyl-6-Fluoro-7-Morpholin-4-Yl-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel antibacterial agents, particularly within the quinolone and naphthyridine antibiotic classes. It is essential for pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the synthesis of next-generation active pharmaceutical ingredients (APIs) targeting resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of potent antibacterial fluoroquinolone and naphthyridine derivatives.
• Antibiotic API Development: Used in research and production of novel antibiotics targeting DNA gyrase and topoisomerase IV enzymes.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize antimicrobial potency and spectrum.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and kilogram-to-ton scale manufacturing of target drug candidates.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical development.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of proprietary drug substances under cGMP conditions.

Basic Information

Product Name	1-Ethyl-6-Fluoro-7-Morpholin-4-Yl-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid
CAS No.	74274-64-9
Molecular Formula	C15H16FN3O4
Molecular Weight	321.31 g/mol
Synonyms	1-Ethyl-6-fluoro-7-(morpholin-4-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 7-(Morpholin-4-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-morpholinyl)-4-oxo-; 74274-64-9; 1-Ethyl-6-fluoro-7-morpholino-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 6-Fluoro-1-ethyl-7-morpholino-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Ethyl-6-Fluoro-7-Morpholin-4-Yl-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities to meet the exacting standards required for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings (e.g., DMF, CMC sections).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.