Description

2-Chloro-3-Pyridinethiol is a versatile sulfur-containing heterocyclic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a chloro and a thiol group on the pyridine ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, leveraging its heterocyclic core for bioactivity.
• Ligand and Catalyst Preparation: Serves as a precursor for metal-chelating ligands used in homogeneous catalysis and material science.
• Functional Material Development: Employed in the research and production of specialty polymers, dyes, and electronic chemicals.
• Chemical Research & Development: A valuable building block for medicinal chemistry, process chemistry, and exploring new synthetic methodologies.

Basic Information

Product Name	2-Chloro-3-Pyridinethiol
CAS No.	74198-95-1
Molecular Formula	C5H4ClNS
Molecular Weight	145.61 g/mol
Synonyms	3-Mercapto-2-chloropyridine; 2-Chloro-3-mercaptopyridine; 2-Chloropyridine-3-thiol; 2-Chloro-3-pyridyl mercaptan; 3-Pyridinethiol, 2-chloro-; 2-Chloro-3-thiopyridinol
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Pyridinethiol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its property of being easily oxidized, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.