Description

2-Bromo-6-(Methylthio)Pyridine is a versatile halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the strategic positioning of the bromine and methylthio groups, which serve as orthogonal handles for selective functionalization via cross-coupling and oxidation reactions. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the pyridine core is a common bioactive motif.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and functionalized polymers.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig amination.
• Sulfur Chemistry Exploration: The methylthio group can be oxidized to sulfoxide or sulfone, or displaced, offering a route to diverse sulfur-containing compounds.

Basic Information

Product Name	2-Bromo-6-(Methylthio)Pyridine
CAS No.	74134-42-2
Molecular Formula	C7H8BrNS
Molecular Weight	218.11 g/mol
Synonyms	2-Bromo-6-methylsulfanylpyridine; 6-Bromo-2-(methylthio)pyridine; 2-Bromo-6-(methylmercapto)pyridine; Pyridine, 2-bromo-6-(methylthio)-; 2-Bromo-6-methylthiopyridine; 2-Methylthio-6-bromopyridine; 6-Bromo-2-methylthiopyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-(Methylthio)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.