Description

1-Fluoro-25-Hydroxyvitamin D3 is a fluorinated analog of the biologically active form of vitamin D, designed for advanced research and development in metabolic pathways. This compound matters for its role as a critical biochemical tool in studying vitamin D receptor (VDR) activity, calcium homeostasis, and cell differentiation with enhanced metabolic stability. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on endocrinology, oncology, and bone metabolism.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for method development and quality control in drug discovery programs targeting vitamin D pathways.
• Biochemical Research: Used as a key reagent to investigate the structure-activity relationship (SAR) of vitamin D analogs and their interaction with the VDR.
• Metabolic Studies: Employed in in vitro and in vivo studies to probe the effects of fluorination on the metabolism and biological activity of calcitriol analogs.
• Probe Compound Development: Acts as a precursor or intermediate in the synthesis of more complex, labeled (e.g., tritiated) or targeted vitamin D receptor modulators.
• Academic & Clinical Research: Supports fundamental research into diseases related to vitamin D deficiency, hyperparathyroidism, psoriasis, and certain cancers.

Basic Information

Product Name	1-Fluoro-25-Hydroxyvitamin D3
CAS No.	74041-09-1
Molecular Formula	C₂₇H₄₃FO₃
Molecular Weight	434.63 g/mol
Synonyms	1α-Fluoro-25-hydroxyvitamin D3; 1α-Fluoro-25-hydroxyvitamin D₃; 1-Fluoro-25-hydroxyvitamin D₃; 1-Fluoro-25-hydroxycholecalciferol; 1α-Fluoro-25-hydroxycholecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-1α-fluoro-3β,25-diol; 1-Fluoro-25-OH-Vitamin D3
EINECS	Contact for details

Quality Control

Our 1-Fluoro-25-Hydroxyvitamin D3 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to minimize moisture exposure. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.