Description

(2S,3R)-2-Hydroxy-3-Methylsuccinic Acid Dimethyl Ester is a high-purity chiral building block and synthetic intermediate of significant commercial interest. Its defined stereochemistry makes it a valuable precursor for the synthesis of complex molecules in regulated industries, where precise molecular architecture is critical. This compound is essential for research and production in pharmaceutical development and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and enzyme inhibitor drug candidates.
• Asymmetric Synthesis: Serves as a versatile starting material or chiral auxiliary in stereoselective reactions to construct complex natural products and fine chemicals.
• Agrochemical Research: Used in the development of novel, stereochemically-defined pesticides and herbicides with enhanced efficacy and selectivity.
• Flavor & Fragrance Industry: Potential precursor for the synthesis of specific chiral flavor compounds and aroma chemicals.
• Academic & Industrial R&D: A critical reagent for methodological development in organic chemistry and catalysis research.
• Biochemical Probe Synthesis: Used to create labeled or modified compounds for studying biological pathways and mechanisms.

Basic Information

Product Name	(2S,3R)-2-Hydroxy-3-Methylsuccinic Acid Dimethyl Ester
CAS No.	73890-17-2
Molecular Formula	C7H12O5
Molecular Weight	176.17 g/mol
Synonyms	Dimethyl (2S,3R)-2-Hydroxy-3-methylsuccinate; (2S,3R)-2-Hydroxy-3-methylbutanedioic Acid Dimethyl Ester; Methyl (2S,3R)-2-Hydroxy-3-methylsuccinate; (2S,3R)-Hydroxymethylsuccinic Acid Dimethyl Ester; (2S,3R)-HMSA Dimethyl Ester; (2S,3R)-2-Hydroxy-3-methyl-1,4-butanedioic Acid Dimethyl Ester; (2S,3R)-O-Methyl 2-hydroxy-3-methylsuccinate
EINECS	Contact for details

Quality Control

Our (2S,3R)-2-Hydroxy-3-Methylsuccinic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.