Description

3-(T-Butyldimethylsiloxy)Propanol is a versatile organosilicon compound featuring a protected hydroxyl group, making it a valuable intermediate in sophisticated organic synthesis. Its primary value lies in its role as a key building block for introducing functionalized propyl chains and as a precursor for further silyl-protected derivatives. This chemical is essential for research and production in the pharmaceutical and fine chemical industries, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring protected alcohol functionalities.
• Nucleoside & Nucleotide Chemistry: Used in the preparation of modified nucleosides and nucleotides for antiviral and anticancer drug development.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) group protects the alcohol during multi-step syntheses, allowing selective reactions at other sites.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for side-chain functionalization in the production of advanced electronic and display materials.
• Polymer Modification: Employed to introduce siloxy-functional side chains into polymers, altering their surface properties and compatibility.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions to form complex carbon-carbon bonds.

Basic Information

Product Name	3-(T-Butyldimethylsiloxy)Propanol
CAS No.	73842-99-6
Molecular Formula	C9H22O2Si
Molecular Weight	190.36 g/mol
Synonyms	3-[(1,1-Dimethylethyl)dimethylsilyl]oxy-1-propanol; 3-(tert-Butyldimethylsilyloxy)-1-propanol; 3-(TBDMS-oxy)propanol; 3-Hydroxypropyl tert-butyldimethylsilyl ether; 1-Propanol, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy-; 3-O-TBDMS-propanol; Propanol, 3-(t-butyldimethylsiloxy)-
EINECS	Contact for details

Quality Control

Our 3-(T-Butyldimethylsiloxy)Propanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using an inert atmosphere or desiccant.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.