Description

tert-Butyl 2-(2-chloroethoxy)acetate is a versatile bifunctional organic intermediate featuring both a chloroethyl ether and a tert-butyl ester group. This compound matters for its role as a key building block in the synthesis of more complex molecules, offering a protected carboxylic acid functionality and a handle for further alkylation or substitution reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing polyethylene glycol (PEG)-like linker chains or side chains in drug molecules.
• Agrochemical Synthesis: Used in the development and production of herbicides, fungicides, and plant growth regulators where its chloro and ester groups allow for modular chemical construction.
• Polymer & Material Science: Serves as a monomer or functionalization agent for creating specialty polymers, coatings, and materials with tailored properties.
• Chemical Research & Development: Employed as a versatile scaffold in medicinal chemistry and organic synthesis for exploring new chemical entities and reaction pathways.
• Linker Chemistry: The chloroethoxy spacer makes it valuable for synthesizing PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs).
• Prodrug Development: The tert-butyl ester acts as a protecting group that can be cleaved under mild acidic conditions, useful in prodrug strategies.

Basic Information

Product Name	tert-Butyl 2-(2-Chloroethoxy)Acetate
CAS No.	73834-55-6
Molecular Formula	C8H15ClO3
Molecular Weight	194.66 g/mol
Synonyms	2-(2-Chloroethoxy)acetic acid tert-butyl ester; Acetic acid, 2-(2-chloroethoxy)-, 1,1-dimethylethyl ester; tert-Butyl (2-chloroethoxy)acetate; 1,1-Dimethylethyl 2-(2-chloroethoxy)acetate; 2-(2-Chloroethoxy)acetic Acid tert-Butyl Ester; tert-Butyl 2-(2-chloroethoxy)ethanoate; TB2CEA
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(2-chloroethoxy)acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets precise customer specifications and industry standards. Certificates of Analysis (COA) with detailed batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.