Description

((4R,5R)-5-(Hydroxymethyl)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)Methyl 4-Methylbenzenesulfonate is a high-value chiral building block and protected intermediate essential for the synthesis of complex organic molecules. Its core value lies in providing a reactive tosylate group on a stereochemically defined, acetonide-protected diol scaffold, enabling precise and efficient downstream chemical transformations. This compound is critically needed by research institutions and pharmaceutical manufacturers engaged in the development of nucleoside analogs, antiviral agents, and other fine chemicals where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of nucleoside and nucleotide analogs with antiviral or anticancer activity.
• Chiral Building Block: Utilized in asymmetric synthesis to introduce stereocenters into complex target molecules, such as sugars and carbocycles.
• Antiviral Drug Research: Serves as a critical intermediate in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Organic Synthesis: The tosylate group acts as an excellent leaving group for nucleophilic substitution reactions, facilitating the introduction of various functional groups.
• Process Chemistry: Employed in scale-up and route development for the commercial manufacturing of optically active compounds.
• Academic Research: Used in methodological studies and the discovery of new synthetic pathways involving protected sugar derivatives.

Basic Information

Item	Detail
Product Name	((4R,5R)-5-(Hydroxymethyl)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)Methyl 4-Methylbenzenesulfonate
CAS No.	73711-65-6
Molecular Formula	C14H20O6S
Molecular Weight	316.37 g/mol
Synonyms	(4R,5R)-5-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate; (4R-cis)-4-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxolanyl methyl p-toluenesulfonate; Isopropylidene-D-glyceraldehyde tosylate derivative; D-Isopropylidene glyceraldehyde tosylate; (R,R)-Isopropylidene glycerol tosylate; 1,2-O-Isopropylidene-α-D-glucofuranose 6-tosylate derivative; Tosylate of protected D-threose; 73711-65-6
EINECS	Contact for details

Quality Control

Our ((4R,5R)-5-(Hydroxymethyl)-2,2-Dimethyl-1,3-Dioxolan-4-Yl)Methyl 4-Methylbenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.