Description

(S)-(+)-1-(1-Naphthyl)Ethyl Isocyanate is a high-purity, chiral isocyanate derivative characterized by its naphthyl group and stereogenic center. This compound matters as a versatile and valuable chiral building block for the synthesis of optically active ureas, carbamates, and other functionalized molecules, enabling precise control over stereochemistry in advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and chiral catalyst development.

Application

• Chiral Auxiliary and Building Block: A key intermediate in the asymmetric synthesis of pharmaceuticals and agrochemicals requiring high enantiomeric purity.
• Chiral Derivatizing Agent: Used for the resolution of racemic mixtures of alcohols and amines via diastereomeric urea or carbamate formation for analytical purposes.
• Ligand Synthesis: Serves as a precursor for the preparation of chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Employed to introduce chiral naphthyl motifs into polymers and resins, modifying their physical and optical properties.
• Pharmaceutical Intermediate: Critical for constructing active pharmaceutical ingredients (APIs) where the (S)-configuration is essential for biological activity.
• Research & Development: A valuable tool in academic and industrial research for exploring new chiral synthetic methodologies and material science.

Basic Information

Product Name	(S)-(+)-1-(1-Naphthyl)Ethyl Isocyanate
CAS No.	73671-79-1
Molecular Formula	C₁₃H₁₁NO
Molecular Weight	197.23 g/mol
Synonyms	(S)-1-(1-Naphthyl)ethyl isocyanate; (S)-(+)-1-(1-Naphthyl)ethyl isocyanate; (S)-1-(Naphthalen-1-yl)ethyl isocyanate; (S)-α-Methyl-1-naphthalenemethyl isocyanate; (+)-(S)-1-(1-Naphthyl)ethyl isocyanate; SEI; (S)-NEI; (S)-1-(1-Naphthyl)ethyl isocyanatobenzene
EINECS	Contact for details

Quality Control

Our (S)-(+)-1-(1-Naphthyl)Ethyl Isocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, open flames, and incompatible materials such as alcohols, amines, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.