Description

3-Chloro-1,2-Propanediol, Di(Trimethylsilyl) Ether is a versatile organosilicon-protected derivative of 3-chloro-1,2-propanediol, serving as a key synthetic intermediate and protecting group reagent. Its primary value lies in its ability to introduce the chlorohydrin moiety in a protected form, enabling complex organic syntheses under anhydrous conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over reactivity in multi-step synthesis.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the controlled introduction of a chlorohydrin or epoxy functional group.
• Agrochemical Synthesis: Serves as a building block for creating herbicides, fungicides, and plant growth regulators.
• Organosilicon Chemistry: Acts as a precursor or reagent in the preparation of more complex siloxanes and silicone-based materials.
• Polymer Modification: Employed to introduce functional groups into polymer chains to alter physical properties like adhesion or solubility.
• Cross-linking Agent: Can be utilized in the production of specialty resins and coatings where controlled cross-linking is desired.
• Laboratory Reagent: Used in research and development for the protection of diols and subsequent selective deprotection strategies.

Basic Information

Product Name	3-Chloro-1,2-Propanediol, Di(Trimethylsilyl) Ether
CAS No.	73639-52-8
Molecular Formula	C9H23ClO2Si2
Molecular Weight	254.90 g/mol
Synonyms	3-Chloro-1,2-propanediol bis(trimethylsilyl) ether; 1,2-Bis(trimethylsilyloxy)-3-chloropropane; 3-Chloropropane-1,2-diyl bis(oxy)bis(trimethylsilane); 3-Chloro-1,2-bis(trimethylsiloxy)propane; Chlorohydrin bis-TMS ether; Glycidol TMS ether derivative; α-Chloroglycerol bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 3-Chloro-1,2-Propanediol, Di(Trimethylsilyl) Ether is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.