Description

Mevastatin CAS NO 73573-88-3 is a potent, naturally occurring statin that serves as a foundational compound in cholesterol biosynthesis research and pharmaceutical development. Its primary value lies in its role as a specific inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway. This makes it an essential biochemical tool and a key intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Pharmaceutical Research & Development: As a prototypical statin, it is a critical reference standard and lead compound for developing new cholesterol-lowering agents and studying their mechanisms of action.
• Biochemical Pathway Studies: Used extensively in laboratory research to inhibit the mevalonate pathway, enabling studies on cholesterol synthesis, isoprenoid metabolism, and related cellular processes.
• Enzyme Inhibition Assays: Serves as a specific inhibitor in in vitro assays to measure HMG-CoA reductase activity and screen for novel inhibitors.
• Academic & Clinical Research: Employed in studies investigating the pleiotropic effects of statins beyond lipid regulation, including impacts on cell proliferation, inflammation, and bone metabolism.
• Chemical Synthesis Intermediate: Acts as a key starting material or precursor in the synthetic pathways for more complex statin molecules and analogs.
• Quality Control & Analytical Standards: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Mevastatin
CAS No.	73573-88-3
Molecular Formula	C23H34O5
Molecular Weight	390.52 g/mol
Synonyms	Compactin; ML-236B; ML236B; (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; 6α-Methylcompactin; Citrinin; Mevastatine; Mevastatinum
EINECS	Contact for details

Quality Control

Our Mevastatin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and identification by IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.