Description

γ-Carboxyglutamic Acid γ,γ-Di-T-Butyl 3-Ethyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical building block for the controlled introduction of γ-carboxyglutamic acid residues, which are vital for the biological activity of various proteins. It is primarily required by research institutions and pharmaceutical companies developing novel therapeutics, particularly in the fields of blood coagulation, bone metabolism, and cardiovascular disease.

Application

• Pharmaceutical Intermediate: Key synthon for the solid-phase and solution-phase synthesis of peptides containing γ-carboxyglutamic acid (Gla) residues.
• Vitamin K-Dependent Protein Research: Used in the study and production of proteins like prothrombin, osteocalcin, and matrix Gla protein.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies for drug candidates targeting coagulation factors and bone mineralization pathways.
• Bioconjugation: The protected ester groups allow for selective deprotection and conjugation strategies in biopharmaceutical development.
• Reference Standard: Serves as a high-purity analytical standard for quality control in peptide API manufacturing.

Basic Information

Product Name	γ-Carboxyglutamic Acid γ,γ-Di-T-Butyl 3-Ethyl Ester
CAS No.	73538-32-6
Molecular Formula	C₁₆H₂₇NO₆
Molecular Weight	329.39 g/mol
Synonyms	γ-Carboxyglutamic Acid γ,γ-Di-tert-Butyl 3-Ethyl Ester; 3-Ethyl γ,γ-di-tert-butyl γ-carboxy-L-glutamate; L-γ-Carboxyglutamic Acid γ,γ-Di-tert-Butyl 3-Ethyl Ester; Boc-Gla(OtBu)-OEt; Fmoc-Gla(OtBu)-OEt (when using Fmoc chemistry); Protected Gla derivative; γ-Carboxyglutamate protected ester; 2-Amino-4-[(tert-butoxy)carbonyl]-4-[(tert-butoxy)carbonyl]aminobutanoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our γ-Carboxyglutamic Acid γ,γ-Di-T-Butyl 3-Ethyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house specifications aligned with ICH guidelines, ensuring the material is suitable for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.