Description

2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester is a key protected intermediate in carbohydrate and medicinal chemistry. This compound is essential for the controlled synthesis of glucuronide derivatives, which are critical for drug metabolism studies and the development of targeted therapeutics. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of advanced glycosides, prodrugs, and biochemical probes.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing drug metabolites, prodrugs, and glucuronide conjugates for pharmacokinetic and ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Biochemical Research: Used in enzymatic and chemical glycosylation reactions to study glucuronosyltransferase activity and to prepare substrates for enzyme inhibition assays.
• Carbohydrate Chemistry: Serves as a protected glucuronic acid donor for the stereoselective synthesis of complex oligosaccharides, glycoconjugates, and natural products.
• Prodrug Development: Employed to create masked drug forms that improve solubility, bioavailability, and targeted delivery, leveraging the glucuronic acid moiety.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Fine Chemical Synthesis: An intermediate in the multi-step synthesis of specialty chemicals, diagnostic agents, and advanced materials requiring specific sugar architectures.

Basic Information

Item	Details
Product Name	2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester
CAS No.	73464-50-3
Molecular Formula	C15H20O12
Molecular Weight	392.31 g/mol
Synonyms	Methyl (2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate); Methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronic acid; β-D-Glucopyranosiduronic acid, methyl 2,3,4-triacetate; Methyl 2,3,4-tri-O-acetyl-1-thio-β-D-glucopyranosiduronate (related); Triacetyl methyl β-D-glucuronate; Glucuronic acid methyl ester triacetate; Protected methyl glucuronate
EINECS	Contact for details

Quality Control

Our 2,3,4-Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide a Certificate of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems support compliance with cGMP and ISO standards for research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.