Description

Polyestradiol is a synthetic estrogen derivative, specifically a polymerized form of estradiol, designed for controlled and sustained release in advanced pharmaceutical applications. Its polymeric structure offers enhanced stability and a modified pharmacokinetic profile compared to the monomeric hormone, making it a critical component in long-term hormone therapy. This compound is primarily utilized by pharmaceutical manufacturers and advanced research institutions developing innovative therapeutic systems for oncology and endocrinology.

Application

• Pharmaceutical Intermediates: Serves as a key starting material or advanced intermediate in the synthesis of specialized hormone-based medications.
• Controlled-Release Drug Delivery Systems: Engineered into implants, microspheres, or polymer matrices for the sustained, long-term administration of estrogen in hormone replacement therapy (HRT).
• Oncological Research: Investigated for use in targeted therapies and as a component in treatments for hormone-sensitive cancers, such as certain breast and prostate cancers.
• Endocrinology and Metabolic Studies: Employed in preclinical and clinical research to study estrogen's effects and develop novel treatment protocols for hormonal disorders.
• Polymer-Prodrug Conjugates: Used in the design of macromolecular prodrugs to improve drug solubility, bioavailability, and tissue-specific targeting.

Basic Information

Item	Detail
Product Name	Polyestradiol
CAS No.	73459-61-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Estradiol Polymer; Poly(estradiol); Polyestradiol Phosphate (related compound); Estradiol Polydisperse; NSC-123127; Polymeric Estradiol; Polyestradiol Steroid Conjugate; Sustained-Release Estradiol Polymer
EINECS	Contact for details

Quality Control

Our Polyestradiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) documenting key parameters such as assay, polymer characteristics, and impurity profiles is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its sensitivity, the material should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and stored away from incompatible substances.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Molecular Weight Distribution (GPC)	Reported on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.