Description

(4S,5S)-Diethyl 2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylate is a high-purity chiral building block and protected tartaric acid derivative essential for asymmetric synthesis. This compound matters for its role as a key intermediate in the production of complex pharmaceuticals, agrochemicals, and fine chemicals, where stereochemical control is paramount. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and advanced material sectors for constructing molecules with defined three-dimensional architectures.

Application

• Chiral Auxiliary and Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis (e.g., for hydrogenation or oxidation reactions).
• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) requiring specific (S,S)-stereochemistry.
• Natural Product Synthesis: Used in the stereoselective construction of complex natural products and biologically active compounds.
• Agrochemical Synthesis: Employed in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Integral to manufacturing specialty chemicals, flavors, and fragrances where optical purity is required.
• Academic and Industrial Research: A valuable reagent for methodological development in organic chemistry and process optimization studies.

Basic Information

Product Name	(4S,5S)-Diethyl 2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylate
CAS No.	73346-73-3
Molecular Formula	C12H20O6
Molecular Weight	260.28 g/mol
Synonyms	(4S,5S)-(-)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylic Acid Diethyl Ester; Diethyl (4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylate; (S,S)-Diethyl Tartrate Acetonide; (4S,5S)-Diethyl 2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylate; L-(+)-Diethyl Tartrate Acetonide; (-)-Diethyl 2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylate; (S,S)-DET Acetonide; Protected Diethyl L-Tartrate
EINECS	Contact for details

Quality Control

Our (4S,5S)-Diethyl 2,2-Dimethyl-1,3-Dioxolane-4,5-Dicarboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and optical purity, meeting the stringent requirements for chiral intermediates. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.