Description

(4R,5R)-4-Acetoxy-1,8,8-Tris(Acetoxymethyl)-4,4Aα,6,7,7Aβ,8,8Aβ,8Bα-Octahydrospiro[5H-Cyclopropa[3,4]Cyclohepta[1,2-C]Pyran-5,2'-Oxirane] is a complex, high-purity organic intermediate characterized by its intricate spirocyclic and polycyclic architecture. This compound is of significant value for advanced organic synthesis, particularly in the development of novel pharmacologically active molecules and complex natural product analogs. It is primarily sought after by research institutions and pharmaceutical development teams working on synthetic methodology and the construction of stereochemically defined molecular scaffolds.

Application

• Advanced Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates, especially those requiring specific stereochemistry.
• Organic Synthesis Research: Used in academic and industrial R&D for exploring new cycloaddition reactions, ring-opening transformations, and the synthesis of novel heterocyclic systems.
• Natural Product Analog Synthesis: Acts as a key precursor for constructing core structures found in or inspired by terpenoids and other complex natural products.
• Chiral Auxiliary/ Ligand Development: Its rigid, multi-chiral structure makes it a candidate for developing new chiral catalysts or ligands for asymmetric synthesis.
• Material Science Research: Potential intermediate for creating specialized monomers or additives aimed at producing polymers with unique thermal or mechanical properties.

Basic Information

Item	Detail
Product Name	(4R,5R)-4-Acetoxy-1,8,8-Tris(Acetoxymethyl)-4,4Aα,6,7,7Aβ,8,8Aβ,8Bα-Octahydrospiro[5H-Cyclopropa[3,4]Cyclohepta[1,2-C]Pyran-5,2'-Oxirane]
CAS No.	73137-02-7
Molecular Formula	C22H28O9
Molecular Weight	436.45 g/mol
Synonyms	1,8,8-Tris(acetoxymethyl)-4-acetoxy-4,4a,6,7,7a,8,8a,8b-octahydrospiro[5H-cyclopropa[3,4]cyclohepta[1,2-c]pyran-5,2'-oxirane]; Spiro[5H-cyclopropa[3,4]cyclohepta[1,2-c]pyran-5,2'-oxirane] derivative; CAS 73137-02-7; (4R,5R)-rel-4-(Acetyloxy)-1,8,8-tris[(acetyloxy)methyl]octahydrospiro[5H-cyclopropa[3,4]cyclohepta[1,2-c]pyran-5,2'-oxirane]; Polyacetoxylated spirocyclic oxirane intermediate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality control protocols to ensure identity, purity, and consistency for sensitive synthetic applications. Standard analytical techniques including HPLC, NMR, and IR spectroscopy are employed. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment to support your research and development documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.