Description

(E)-4-[4-[Bis(2-Chloroethyl)Amino]Phenyl]-3-Butenoic Acid is a specialized synthetic intermediate of significant interest in advanced organic synthesis. Its molecular structure, featuring a chlorinated nitrogen mustard moiety conjugated to a phenyl butenoic acid chain, makes it a valuable precursor for constructing complex pharmacologically active molecules. This compound is primarily sought by research institutions and pharmaceutical development companies engaged in the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the research and development of novel anticancer agents and targeted therapies.
• Bioconjugation Chemistry: Used in the synthesis of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in oncology and other disease areas.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying cellular mechanisms and protein interactions.
• Advanced Organic Synthesis: Employed in multi-step syntheses requiring a bifunctional linker with specific reactivity profiles.

Basic Information

Product Name	(E)-4-[4-[Bis(2-Chloroethyl)Amino]Phenyl]-3-Butenoic Acid
CAS No.	73027-06-2
Molecular Formula	C14H17Cl2NO2
Molecular Weight	302.20 g/mol
Synonyms	(E)-4-[4-[Bis(2-chloroethyl)amino]phenyl]but-3-enoic acid; 4-[p-[Bis(2-chloroethyl)amino]phenyl]-3-butenoic acid; (E)-4-(4-(Bis(2-chloroethyl)amino)phenyl)but-3-enoic acid; NSC 338720; Chlorambucil analogue intermediate; p-[N,N-Bis(2-chloroethyl)amino]cinnamic acid derivative
EINECS	Contact for details

Quality Control

Every batch of (E)-4-[4-[Bis(2-Chloroethyl)Amino]Phenyl]-3-Butenoic Acid is manufactured under strict quality management protocols. We provide comprehensive analytical documentation to support research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot, ensuring traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.