Description

3-Chloroisonicotinaldehyde is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an aldehyde and a chloro substituent on the pyridine ring, makes it a valuable precursor for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This high-purity intermediate is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the chloropyridine moiety.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its reactive aldehyde group.
• Chemical Biology Probes: Utilized to create molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-Chloroisonicotinaldehyde
CAS No.	72990-37-5
Molecular Formula	C6H4ClNO
Molecular Weight	141.55 g/mol
Synonyms	3-Chloro-4-formylpyridine; 3-Chloro-4-pyridinecarboxaldehyde; 4-Pyridinecarboxaldehyde, 3-chloro-; 3-Chloroisonicotinaldehyde; 3-Chloro-4-pyridylcarboxaldehyde; Isonicotinaldehyde, 3-chloro-; 3-Chloropyridine-4-carbaldehyde
EINECS	Contact for details

Quality Control

Our 3-Chloroisonicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.