Description

5-Thiazolecarboxylicacid,2-Fluoro-4-(Trifluoromethyl)-,Ethylester(9Ci) CAS NO 72850-80-7 is a high-purity fluorinated thiazole derivative, a crucial advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which combines a fluorine atom and a trifluoromethyl group on the thiazole ring, enabling precise modulation of electronic and steric properties in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorinated thiazole core contributes to improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized heterocycles in the development of specialty polymers, liquid crystals, or organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in the study of biological processes and protein interactions due to its distinctive fluorine signature.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	5-Thiazolecarboxylicacid,2-Fluoro-4-(Trifluoromethyl)-,Ethylester(9Ci)
CAS No.	72850-80-7
Molecular Formula	C8H5F4NO2S
Molecular Weight	255.19 g/mol
Synonyms	2-Fluoro-4-(trifluoromethyl)thiazole-5-carboxylic acid ethyl ester; Ethyl 2-fluoro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate; 2-Fluoro-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester; 5-Thiazolecarboxylic acid, 2-fluoro-4-(trifluoromethyl)-, ethyl ester; 72850-80-7; Ethyl 2-fluoro-4-(trifluoromethyl)-5-thiazolecarboxylate
EINECS	Contact for details

Quality Control

Our production of 5-Thiazolecarboxylicacid,2-Fluoro-4-(Trifluoromethyl)-,Ethylester(9Ci) adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.