Description

(R)-1-Thia-4-Aza-Spiro[4.4]Nonane-3-Carboxylic Acid is a high-purity, chiral spirocyclic building block of significant interest in advanced organic synthesis. Its unique constrained spirocyclic structure, incorporating both sulfur and nitrogen heteroatoms, makes it a valuable scaffold for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, particularly where three-dimensional shape and specific stereochemistry are critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in protease inhibitor and central nervous system (CNS) targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where its spirocyclic core contributes to unique binding properties.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis, leveraging its rigid, three-dimensional framework.
• Chemical Biology Probes: Employed in the design of molecular probes to study enzyme function and protein-protein interactions.
• Peptidomimetics: The carboxylic acid functionality and constrained ring system make it suitable for creating conformationally restricted peptide analogs.

Basic Information

Product Name	(R)-1-Thia-4-Aza-Spiro[4.4]Nonane-3-Carboxylic Acid
CAS No.	72744-86-6
Molecular Formula	C7H9NO2S
Molecular Weight	171.22 g/mol
Synonyms	(R)-1-Thia-4-azaspiro[4.4]nonane-3-carboxylic acid; (3R)-1-Thia-4-azaspiro[4.4]nonane-3-carboxylic acid; (R)-Thia-azaspiro[4.4]nonane-3-carboxylic acid; (R)-TANS-3-COOH; (R)-1-Thia-4-aza-spiro[4.4]nonane-3-carboxylic acid; (R)-Spirocyclic Thiaza Amino Acid; (R)-1-Thia-4-aza-spiro[4.4]nonane-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-1-Thia-4-Aza-Spiro[4.4]Nonane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.