Description

(+)-Ethyl (R)-3-Hydroxy-3-Phenylpropionate CAS NO 72656-47-4 is a high-purity chiral intermediate of significant importance in asymmetric synthesis. Its defined stereochemistry makes it a valuable building block for the production of optically active pharmaceuticals and fine chemicals. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce a chiral β-hydroxy ester moiety into complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drugs.
• Asymmetric Synthesis: Used as a starting material or building block in stereoselective reactions, including aldol additions and reductions.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and other high-value specialty chemicals requiring specific enantiomeric purity.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where biological activity is enantiomer-dependent.
• Catalyst and Ligand Synthesis: Utilized in the preparation of chiral catalysts and ligands for homogeneous catalysis.
• Academic & R&D: A standard reagent in university and corporate research laboratories for methodological development in organic chemistry.

Basic Information

Product Name	(+)-Ethyl (R)-3-Hydroxy-3-Phenylpropionate
CAS No.	72656-47-4
Molecular Formula	C11H14O3
Molecular Weight	194.23 g/mol
Synonyms	(R)-Ethyl 3-Hydroxy-3-phenylpropanoate; Ethyl (R)-3-Hydroxy-3-phenylpropionate; (R)-3-Hydroxy-3-phenylpropionic Acid Ethyl Ester; (R)-(-)-Ethyl 3-Hydroxy-3-phenylpropanoate; (R)-β-Hydroxy-β-phenylpropionic Acid Ethyl Ester; Ethyl (R)-β-Hydroxyhydrocinnamate; (R)-Hydroxyphenylpropionic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our (+)-Ethyl (R)-3-Hydroxy-3-Phenylpropionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.