Description

Methyl 3-(2,5-Dioxopyrrolidin-1-Yl)Benzoate is a high-purity chemical intermediate featuring a reactive N-hydroxysuccinimide (NHS) ester group, enabling efficient conjugation with primary amines. This compound is critical for researchers and manufacturers requiring reliable, high-yield amide bond formation under mild conditions. It is primarily utilized in the synthesis of advanced pharmaceutical compounds, bioconjugates, and specialized materials where precise molecular coupling is essential.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly for targeted therapies.
• Bioconjugation & Labeling: Used to covalently attach drugs, fluorophores, or other functional molecules to proteins, antibodies, peptides, and nanoparticles.
• Proteomics Research: Employed in chemical cross-linking and affinity purification workflows for studying protein-protein interactions.
• Polymer & Material Science: Serves as a functional monomer or cross-linker for creating smart polymers, hydrogels, and surface-modified materials.
• Diagnostic Reagent Synthesis: Integral in manufacturing components for immunoassays and biosensors that require stable amine-reactive linkers.

Basic Information

Product Name	Methyl 3-(2,5-Dioxopyrrolidin-1-Yl)Benzoate
CAS No.	72601-52-6
Molecular Formula	C13H13NO5
Molecular Weight	263.25 g/mol
Synonyms	3-(2,5-Dioxo-1-pyrrolidinyl)benzoic acid methyl ester; Methyl 3-(N-succinimidyl)benzoate; 3-(N-Succinimidyl)benzoic acid methyl ester; 1-(3-Methoxycarbonylphenyl)pyrrolidine-2,5-dione; Benzoic acid, 3-(2,5-dioxo-1-pyrrolidinyl)-, methyl ester; NHS-activated methyl benzoate derivative; Methyl 3-(NHS)benzoate
EINECS	Contact for details

Quality Control

Our Methyl 3-(2,5-Dioxopyrrolidin-1-Yl)Benzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.