Description

2-Chloro-3-Fluoro-5-(Trifluoromethyl)Pyridine is a high-value fluorinated pyridine derivative, a crucial building block in modern synthetic chemistry. Its unique structure, featuring multiple halogen substituents, makes it an essential intermediate for creating advanced molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty chemicals, liquid crystals, and functional materials requiring specific electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Stille) to construct complex biaryl systems common in modern chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	2-Chloro-3-Fluoro-5-(Trifluoromethyl)Pyridine
CAS No.	72600-67-0
Molecular Formula	C6H2ClF4N
Molecular Weight	199.53 g/mol
Synonyms	2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-chloro-3-fluoropyridine; Pyridine, 2-chloro-3-fluoro-5-(trifluoromethyl)-; 2-Chloro-3-fluoro-5-trifluoromethylpyridine; 3-Fluoro-2-chloro-5-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoro-5-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, with specifications typically meeting or exceeding industry standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by GC/HPLC), and impurity profiles is provided with each shipment to ensure full traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reactive metals. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.